This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …

Current concepts of corticothalamic organization in the mammalian brain are mainly based
on sensory systems, with less focus on circuits for higher-order cognitive functions. In …

Lack of behavioral suppression typifies substance use disorders, yet the neural circuit
underpinnings of drug-induced behavioral disinhibition remain unclear. Here, we employ …

The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive
and behavioral processes. However, while functional diversity among PVT circuits has often …

Head-fixed behavioral experiments in rodents permit unparalleled experimental control,
precise measurement of behavior, and concurrent modulation and measurement of neural …

The prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for
neuroadaptations in alcohol use disorders. Recent advances in genetically encoded …

The successful pursuit of goals requires the coordinated execution and termination of
actions that lead to positive outcomes. This process relies on motivational states that are …

Corticothalamic projections to sensorimotor thalamic nuclei show modest firing rates and
serve to modulate the activity of thalamic relay neurons. By contrast, here we find that high …

The concept of ligand bias is based on the premise that different agonists can elicit distinct
responses by selectively activating the same receptor. These responses often determine …