Application of ω-Transaminases in the Pharmaceutical Industry
SA Kelly, S Pohle, S Wharry, S Mix, CCR Allen… - Chemical …, 2018 - ACS Publications
Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …
reductive amination is one of the most efficient and atom economic methodologies for the …
Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates
Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make
manufacturing processes greener and more sustainable. Biocatalysts that possess excellent …
manufacturing processes greener and more sustainable. Biocatalysts that possess excellent …
Oxidoreductase-catalyzed synthesis of chiral amines
Chiral amines are valuable constituents of many important pharmaceutical compounds and
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …
The industrial age of biocatalytic transamination
M Fuchs, JE Farnberger… - European Journal of …, 2015 - Wiley Online Library
During the last decade the use of ω‐transaminases has been identified as a very powerful
method for the preparation of optically pure amines from the corresponding ketones. Their …
method for the preparation of optically pure amines from the corresponding ketones. Their …
Amine transaminases in chiral amines synthesis: recent advances and challenges
EE Ferrandi, D Monti - World Journal of Microbiology and Biotechnology, 2018 - Springer
Transaminases, which catalyze the stereoselective transfer of an amino group between an
amino donor and a prochiral ketone substrate, are interesting biocatalytic tools for the …
amino donor and a prochiral ketone substrate, are interesting biocatalytic tools for the …
From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination
A commercially available ruthenium (II) PNP-type pincer catalyst (Ru-Macho) promotes the
formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and …
formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and …
The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions
P Kelefiotis-Stratidakis, T Tyrikos-Ergas… - Organic & Biomolecular …, 2019 - pubs.rsc.org
Amine transaminases (ATAs) propose an appealing alternative to transition metal catalysts
as they can provide chiral amines of high purity from pro-chiral compounds by asymmetric …
as they can provide chiral amines of high purity from pro-chiral compounds by asymmetric …
Direct asymmetric reductive amination of alkyl (hetero) aryl ketones by an engineered amine dehydrogenase
W Kong, Y Liu, C Huang, L Zhou, J Gao… - Angewandte …, 2022 - Wiley Online Library
The direct asymmetric reductive amination of heteroaryl ketones has been a long‐standing
synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) …
synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) …
Synthesizing chiral drug intermediates by biocatalysis
W Jiang, B Fang - Applied Biochemistry and Biotechnology, 2020 - Springer
The chiral feature is a critical factor for the efficacy and safety of many therapeutic agents. At
present, about 57% of marketed drugs are chiral drugs and about 99% of purified natural …
present, about 57% of marketed drugs are chiral drugs and about 99% of purified natural …