Multifunctional fructose 1, 6-bisphosphate aldolase as a therapeutic target

DB Pirovich, AA Da'dara, PJ Skelly - Frontiers in molecular …, 2021 - frontiersin.org
Fructose 1, 6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the
fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and …

Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases

DA Ayón-Núñez, G Fragoso, RJ Bobes… - Bioscience …, 2018 - portlandpress.com
Pathogens have developed particular strategies to infect and invade their hosts. Amongst
these strategies' figures the modulation of several components of the innate immune system …

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis*[S]

K Cwiklinski, E de la Torre-Escudero, M Trelis… - Molecular & Cellular …, 2015 - ASBMB
Extracellular vesicles (EVs) released by parasites have important roles in establishing and
maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola …

Hyperfibrinolysis and Hypofibrinogenemia Diagnosed With Rotational Thromboelastometry in Dogs Naturally Infected With Angiostrongylus vasorum

NE Sigrist, N Hofer‐Inteeworn… - Journal of veterinary …, 2017 - Wiley Online Library
Background The pathomechanism of Angiostrongylus vasorum infection‐associated
bleeding diathesis in dogs is not fully understood. Objective To describe rotational …

Moonlighting proteins as virulence factors of pathogenic fungi, parasitic protozoa and multicellular parasites

J Karkowska‐Kuleta, A Kozik - Molecular Oral Microbiology, 2014 - Wiley Online Library
The delicate balance between eukaryotic pathogens and their human hosts during the
initiation and development of infection is a complex process involving many diverse …

The Anisakis Transcriptome Provides a Resource for Fundamental and Applied Studies on Allergy-Causing Parasites

FJ Baird, X Su, I Aibinu, MJ Nolan… - PLoS Neglected …, 2016 - journals.plos.org
Background Food-borne nematodes of the genus Anisakis are responsible for a wide range
of illnesses (= anisakiasis), from self-limiting gastrointestinal forms to severe systemic …

A review of hyperfibrinolysis in cats and dogs

R Birkbeck, K Humm, S Cortellini - Journal of Small Animal …, 2019 - Wiley Online Library
The fibrinolytic system is activated concurrently with coagulation; it regulates haemostasis
and prevents thrombosis by restricting clot formation to the area of vascular injury and …

The Angiostrongylus vasorum Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation

N Gillis-Germitsch, T Kockmann, LM Asmis… - Frontiers in Cellular …, 2021 - frontiersin.org
Angiostrongylus vasorum is a cardiopulmonary nematode of canids and is, among others,
associated with bleeding disorders in dogs. The pathogenesis of such coagulopathies …

Hemostatic Dysfunction in Dogs Naturally Infected with Angiostrongylus vasorum—A Narrative Review

JL Willesen, R Langhorn, LN Nielsen - Pathogens, 2022 - mdpi.com
This narrative review aims to describe Angiostrongylus vasorum-induced hemostatic
dysfunction of dogs with emphasis on clinical and laboratory findings as well as potential …

Parasitism in optima forma: exploiting the host fibrinolytic system for invasion

L Figuera, A Gómez-Arreaza, L Avilán - Acta Tropica, 2013 - Elsevier
The interaction of pathogenic bacteria with the host fibrinolytic system through the
plasminogen molecule has been well documented. It has been shown, using animal …