Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to
their potential cost-effectiveness, scalability and on-demand availability. However, immune …

Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity
against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is …

Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for
treatment of various malignancies. In this study, we used a genome-wide CRISPR screen to …

Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells
can persist by evading immune surveillance. To investigate the genetic mechanisms …

There is growing recognition of the importance of sialylation as a critical post translational
modification in cancer. In this article we review the role of increased cell surface sialylation …

Glycosylation of proteins and lipids is of fundamental importance in multicellular eukaryotes.
The vast diversity of glycan structures observed is generated in the Golgi apparatus by the …

The inhibitory receptor NKG2A, which forms a heterodimer with CD94, is expressed by~
50% of peripheral blood NK cells and is further upregulated following NK cell expansion ex …

G protein–coupled receptors (GPCRs) represent the largest family of surface receptors and
are responsible for key physiological functions, including cell growth, neurotransmission …

Background Immune checkpoint blockade targeting the adaptive immune system has
revolutionized the treatment of cancer. Despite impressive clinical benefits observed, patient …

Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and
hold promise in the development of new immunotherapies. This article for the Highlights of …