Clinical history, questionnaire data and response to antisecretory therapy are insufficient to
make a conclusive diagnosis of GERD in isolation, but are of value in determining need for …

Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate
into the esophagus or beyond, resulting in either troublesome symptoms or complications …

Background An international group of experts evaluated and revised recommendations for
ambulatory reflux monitoring for the diagnosis of gastro‐esophageal reflux disease (GERD) …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

The gastrointestinal mucosal barrier plays an essential role in the separation of the inside of
the body from the outside environment. Tight junctions (TJs) are the most important …

Background Ineffective esophageal motility (IEM) is a heterogenous minor motility disorder
diagnosed when≥ 50% ineffective peristaltic sequences (distal contractile integral< 450 mm …

Background & Aims Mucosal integrity can be assessed in patients with gastroesophageal
reflux disease (GERD) by measuring intraluminal baseline impedance (BI). However, it is …

Die gastroösophageale Refluxkrankheit gehört zur häufigsten organischen
Oberbaucherkrankung. Zwar hat eine Klasse von Säurehemmern …

Methods Fifty proton pump inhibitotor refractory patients (11 male, 48 years [range, 38–57
years]) with a diagnosis of functional heart-burn according to Rome III in the first 24 hours of …

In general, gastroesophageal reflux disease (GERD) is diagnosed clinically based on typical
symptoms and/or response to proton pump inhibitor treatment. Upper gastrointestinal …