A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …

Motivation: The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive
immunity and is thus relevant in many biomedical applications. While next-generation …

Detection of somatic mutations in human leukocyte antigen (HLA) genes using whole-
exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which …

Utilization of negative checkpoint regulators (NCR s) for cancer immunotherapy has
garnered significant interest with the completion of clinical trials demonstrating efficacy …

The accurate typing of human leukocyte antigen (HLA) alleles is critical for a variety of
medical applications, such as genomic studies of multifactorial diseases, including immune …

Tumor progression is typically accompanied by an accumulation of driver and passenger
somatic mutations. A handful of those mutations occur in protein coding genes which …

In the past decade, the development of next-generation sequencing (NGS) has paved the
way for whole-genome analysis in individuals. Research on the human leukocyte antigen …

Somatic mutations binding to the patient's MHC and recognized by autologous T cells
(neoepitopes) are ideal cancer vaccine targets. They combine a favorable safety profile due …

Background Accurate HLA typing at amino acid level (four-digit resolution) is critical in
hematopoietic and organ transplantations, pathogenesis studies of autoimmune and …