MYC oncogene contributions to release of cell cycle brakes
Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …
Integrating genetic approaches into the discovery of anticancer drugs
LH Hartwell, P Szankasi, CJ Roberts, AW Murray… - Science, 1997 - science.org
The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …
Oncogenic transcription factors in the human acute leukemias
AT Look - Science, 1997 - science.org
Chromosomal translocations in the human acute leukemias rearrange the regulatory and
coding regions of a variety of transcription factor genes. The resultant protein products can …
coding regions of a variety of transcription factor genes. The resultant protein products can …
The biology of CML blast crisis
B Calabretta, D Perrotti - Blood, 2004 - ashpublications.org
Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …
The many roles of c-Myc in apoptosis
EB Thompson - Annual review of physiology, 1998 - annualreviews.org
▪ Abstract The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great
importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled …
importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled …
Nucleic acid therapeutics: state of the art and future prospects
AM Gewirtz, DL Sokol… - Blood, The Journal of the …, 1998 - ashpublications.org
AS WE APPROACH the new millennium, a quick glance backwards reveals that truly
astounding progress has been made in the identification of genes responsible for cell …
astounding progress has been made in the identification of genes responsible for cell …
BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia
S Salesse, CM Verfaillie - Oncogene, 2002 - nature.com
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder resulting from the
clonal expansion of a transformed multipotent hematopoietic stem cell. CML is a biphasic …
clonal expansion of a transformed multipotent hematopoietic stem cell. CML is a biphasic …
BCR/ABL activates mdm2 mRNA translation via the La antigen
R Trotta, T Vignudelli, O Candini, RV Intine, L Pecorari… - Cancer cell, 2003 - cell.com
In a BCR/ABL-expressing myeloid precursor cell line, p53 levels were markedly
downmodulated. Expression of MDM2, the negative regulator of p53, was upregulated in a …
downmodulated. Expression of MDM2, the negative regulator of p53, was upregulated in a …
A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation
Altered mRNA translation is one of the effects exerted by the BCR/ABL oncoprotein in the
blast crisis phase of chronic myelogenous leukemia (CML). Here, we report that in …
blast crisis phase of chronic myelogenous leukemia (CML). Here, we report that in …
Chronic myelogenous leukemia: mechanisms underlying disease progression
AS Shet, BN Jahagirdar, CM Verfaillie - Leukemia, 2002 - nature.com
Chronic myelogenous leukemia (CML), characterized by the BCR-ABL gene rearrangement,
has been extensively studied. Significant progress has been made in the area of BCR-ABL …
has been extensively studied. Significant progress has been made in the area of BCR-ABL …