Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

KR Paudel, M Mehta, GHS Yin, LL Yen… - … Science and Pollution …, 2022 - Springer
Non-small cell lung cancer (NSCLC) is reported to have a high incidence rate and is one of
the most prevalent types of cancer contributing towards 85% of all incidences of lung cancer …

Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in 16HBE …

KR Paudel, N Panth, B Manandhar, SK Singh, G Gupta… - Antioxidants, 2022 - mdpi.com
Cigarette smoke is considered a primary risk factor for chronic obstructive pulmonary
disease. Numerous toxicants present in cigarette smoke are known to induce oxidative …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro

B Manandhar, KR Paudel, DD Clarence… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the second most prevalent type of cancer and is responsible for the highest
number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up …

Phytantriol-based berberine-loaded liquid crystalline nanoparticles attenuate inflammation and oxidative stress in lipopolysaccharide-induced RAW264. 7 …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Nanomaterials, 2022 - mdpi.com
Inflammation and oxidative stress are interrelated processes that represent the underlying
causes of several chronic inflammatory diseases that include asthma, cystic fibrosis, chronic …

Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases

M Mehta, KR Paudel, SD Shukla, VSRR Allam… - Journal of Controlled …, 2021 - Elsevier
Nuclear factor κB (NFκB) is a unique protein complex that plays a major role in lung
inflammation and respiratory dysfunction. The NFκB signaling pathway, therefore becomes …

Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma

VSRR Allam, KR Paudel, G Gupta, SK Singh… - … Science and Pollution …, 2022 - Springer
Asthma is a chronic inflammatory disease primarily characterized by inflammation and
reversible bronchoconstriction. It is currently one of the leading causes of morbidity and …

Agarwood oil nanoemulsion counteracts LPS-induced inflammation and oxidative stress in RAW264. 7 mouse macrophages

R Malik, KR Paudel, B Manandhar, G De Rubis… - … -Research and Practice, 2023 - Elsevier
Purpose Oxidative stress and inflammation are key pathophysiological features of chronic
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …