Since the last century, peptides have gained wide acceptance as drugs, with almost 100
already in the market and a large number in the pipeline. In this context, peptide synthesis …

The biocatalytic stereocontrolled synthesis of various acyclic anti-or syn-α-alkyl-β-amino
amides through a dynamic kinetic resolution strategy is demonstrated. A series of …

An effective chiral GAP methodology for preparing α‐aminomethyl enaminones through a
(R)‐CSA‐catalyzed asymmetric aza‐Baylis‐Hillman reaction is reported. Excellent yields …

A highly diastereoselective and enantioselective Michael addition of enolizable ketones
such as cyclohexanone and acetophenone to a variety of substituted trans‐β‐nitrostyrenes …

The synthesis of several novel organocatalysts derived from (R)-and (S)-proline-glycine
dipeptides and incorporating a chiral phosphoramide fragment was accomplished. These …

The synthesis and evaluation of three novel chiral organocatalysts derived from (S)-proline
and containing a bis-amidophosphoryl amine fragment are reported. The structure and …

Novel organocatalysts derived from (R)-and (S)-proline and incorporating a chiral
phosphoramide fragment were rationally designed and subsequently synthesized. These …

Methyl (S)-4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate has been synthesized for enzymatic
studies on cyclization enzymes during cocaine biosynthesis in Erythroxylum coca plants …

This chapter covers chemistry, manufacturing, and controls (CMC) aspects based on the
quality vision of synthetically manufactured oligonucleotides as active pharmaceutical …

Figure 2.1 Biologically Active Enaminones Enaminones framework widely exist in
biologically active substances (Figure 2.1) such as the anticonvulsant (type I), 56 natural …