Informing deep neural networks by multiscale principles of neuromodulatory systems

J Mei, E Muller, S Ramaswamy - Trends in Neurosciences, 2022 - cell.com
Our brains have evolved the ability to configure and adapt their processing states to match
the unique challenges of acting and learning in diverse environments and behavioral …

The mesencephalic locomotor region: multiple cell types, multiple behavioral roles, and multiple implications for disease

D Ryczko - The Neuroscientist, 2024 - journals.sagepub.com
The mesencephalic locomotor region (MLR) controls locomotion in vertebrates. In humans
with Parkinson disease, locomotor deficits are increasingly associated with decreased …

[HTML][HTML] A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang… - Cell, 2022 - cell.com
Motor behaviors are often planned long before execution but only released after specific
sensory events. Planning and execution are each associated with distinct patterns of motor …

[HTML][HTML] Modulation of motor behavior by the mesencephalic locomotor region

D Dautan, A Kovács, T Bayasgalan, MA Diaz-Acevedo… - Cell reports, 2021 - cell.com
The mesencephalic locomotor region (MLR) serves as an interface between higher-order
motor systems and lower motor neurons. The excitatory module of the MLR is composed of …

Rapid effects of vagus nerve stimulation on sensory processing through activation of neuromodulatory systems

C Rodenkirch, JB Carmel, Q Wang - Frontiers in neuroscience, 2022 - frontiersin.org
After sensory information is encoded into neural signals at the periphery, it is processed
through multiple brain regions before perception occurs (ie, sensory processing). Recent …

Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

D Dautan, I Huerta-Ocampo, NK Gut, M Valencia… - Nature …, 2020 - nature.com
Assimilation of novel strategies into a consolidated action repertoire is a crucial function for
behavioral adaptation and cognitive flexibility. Acetylcholine in the striatum plays a pivotal …

Ten key reasons for continuing research on pharmacotherapy for post-stroke aphasia

ML Berthier - Aphasiology, 2021 - Taylor & Francis
Background: Aphasia is a devastating disorder occurring in more than 30% of stroke victims.
Speech and language therapy (SLT) is the treatment of choice for post-stroke aphasia (PSA) …

Brain‐wide mapping of inputs to the mouse lateral posterior (LP/pulvinar) thalamus–anterior cingulate cortex network

YN Leow, B Zhou, HA Sullivan… - Journal of …, 2022 - Wiley Online Library
The rodent homolog of the primate pulvinar, the lateral posterior (LP) thalamus, is
extensively interconnected with multiple cortical areas. While these cortical interactions can …

[HTML][HTML] EEG, MEG and neuromodulatory approaches to explore cognition: Current status and future directions

C Beppi, IR Violante, G Scott, S Sandrone - Brain and Cognition, 2021 - Elsevier
Neural oscillations and their association with brain states and cognitive functions have been
object of extensive investigation over the last decades. Several electroencephalography …

Mapping cholinergic synaptic loss in Parkinson's disease: An [18F] FEOBV PET case-control study

J Horsager, N Okkels, AK Hansen… - Journal of …, 2022 - content.iospress.com
Background: Cholinergic degeneration is strongly associated with cognitive decline in
patients with Parkinson's disease (PD) but may also cause motor symptoms and olfactory …