Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Z Ismail, B Creese, D Aarsland, HC Kales… - Nature Reviews …, 2022 - nature.com
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Assessment and management of behavioral and psychological symptoms of dementia

HC Kales, LN Gitlin, CG Lyketsos - Bmj, 2015 - bmj.com
Behavioral and psychological symptoms of dementia include agitation, depression, apathy,
repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of …

Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis

JL Liss, S Seleri Assunção, J Cummings… - Journal of internal …, 2021 - Wiley Online Library
The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention,
diagnosis and management must evolve as new treatment paradigms and disease …

[HTML][HTML] Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

KL Lanctôt, J Amatniek, S Ancoli-Israel… - Alzheimer's & Dementia …, 2017 - Elsevier
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia

VI Reus, LJ Fochtmann, AE Eyler… - American Journal of …, 2016 - Am Psychiatric Assoc
The goal of this guideline is to improve the care of patients with dementia who are exhibiting
agitation or psychosis. More specifically, this guideline focuses on the judicious use of …

Evidence-based nonpharmacological practices to address behavioral and psychological symptoms of dementia

K Scales, S Zimmerman, SJ Miller - The Gerontologist, 2018 - academic.oup.com
Abstract Background and Objectives To draw from systematic and other literature reviews to
identify, describe, and critique nonpharmacological practices to address behavioral and …

The Mild Behavioral Impairment Checklist (MBI-C): a rating scale for neuropsychiatric symptoms in pre-dementia populations

Z Ismail, L Agüera-Ortiz, H Brodaty… - Journal of …, 2017 - content.iospress.com
Background: Mild behavioral impairment (MBI) is a construct that describes the emergence
at≥ 50 years of age of sustained and impactful neuropsychiatric symptoms (NPS), as a …

Best practice in the management of behavioural and psychological symptoms of dementia

OP Tible, F Riese, E Savaskan… - Therapeutic advances …, 2017 - journals.sagepub.com
Behavioural and psychological symptoms of dementia (BPSD) occur in most patients with
dementia. They cause great suffering in patients and caregivers, sometimes more so than …

Executive functions in Alzheimer disease: A systematic review

A Guarino, F Favieri, I Boncompagni… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease is a severe irreversible syndrome, characterized by a slow and
progressive cognitive decline that interferes with the standard instrumental and essential …

Effect of methylphenidate on apathy in patients with Alzheimer disease: the ADMET 2 randomized clinical trial

J Mintzer, KL Lanctôt, RW Scherer… - JAMA …, 2021 - jamanetwork.com
Importance Apathy, characterized by diminished will or initiative and one of the most
prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated …