Antiviral potential of nanoparticles—can nanoparticles fight against coronaviruses?

S Gurunathan, M Qasim, Y Choi, JT Do, C Park… - Nanomaterials, 2020 - mdpi.com
Infectious diseases account for more than 20% of global mortality and viruses are
responsible for about one-third of these deaths. Highly infectious viral diseases such as …

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

N Jeelan Basha, SM Basavarajaiah, K Shyamsunder - Molecular Diversity, 2022 - Springer
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …

The acid sphingomyelinase/ceramide system in COVID-19

J Kornhuber, N Hoertel, E Gulbins - Molecular Psychiatry, 2022 - nature.com
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

A novel cell culture system modeling the SARS-CoV-2 life cycle

X Ju, Y Zhu, Y Wang, J Li, J Zhang, M Gong… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the global
pandemic of COVID-19. SARS-CoV-2 is classified as a biosafety level-3 (BSL-3) agent …

[HTML][HTML] Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities

M Kumar, M Tomar, DJ Bhuyan, S Punia… - Biomedicine & …, 2021 - Elsevier
The processing of tomato fruit into puree, juices, ketchup, sauces, and dried powders
generates a significant amount of waste in the form of tomato pomace, which includes seeds …

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

H Ohashi, K Watashi, W Saso, K Shionoya, S Iwanami… - Iscience, 2021 - cell.com
Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute …

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review

S Masyeni, M Iqhrammullah… - Journal of Medical …, 2022 - Wiley Online Library
Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

M Dittmar, JS Lee, K Whig, E Segrist, M Li, B Kamalia… - Cell reports, 2021 - cell.com
There is an urgent need for antivirals to treat the newly emerged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …

UVC-based photoinactivation as an efficient tool to control the transmission of coronaviruses

SK Bhardwaj, H Singh, A Deep, M Khatri… - Science of The Total …, 2021 - Elsevier
The ongoing COVID-19 pandemic made us re-realize the importance of environmental
disinfection and sanitation in indoor areas, hospitals, and clinical rooms. UVC irradiation of …

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro

S Schloer, L Brunotte… - British journal of …, 2021 - Wiley Online Library
Background and Purpose The SARS‐COV‐2 pandemic and the global spread of
coronavirus disease 2019 (COVID‐19) urgently call for efficient and safe antiviral treatment …