A Compressive Review about Taxol®: History and Future Challenges

J Gallego-Jara, G Lozano-Terol, RA Sola-Martínez… - Molecules, 2020 - mdpi.com
Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat
different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to …

Persistent cancer cells: the deadly survivors

S Shen, S Vagner, C Robert - Cell, 2020 - cell.com
Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug
treatment and constitute a major cause of treatment failure. These cells are characterized by …

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming

L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti - Drug Resistance Updates, 2021 - Elsevier
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Stimuli responsive nanosonosensitizers for sonodynamic therapy

Z Jiang, W Xiao, Q Fu - Journal of Controlled Release, 2023 - Elsevier
Sonodynamic therapy (SDT) has gained significant attention in the treatment of deep tumors
and multidrug-resistant (MDR) bacterial infections due to its high tissue penetration depth …

[HTML][HTML] Mechanism of drug tolerant persister cancer cells: the landscape and clinical implication for therapy

M Mikubo, Y Inoue, G Liu, MS Tsao - Journal of Thoracic Oncology, 2021 - Elsevier
A minor population of cancer cells may evade cell death from chemotherapy and targeted
therapy by entering a reversible slow proliferation state known as the drug tolerant persister …

[HTML][HTML] Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells

K Szebényi, A Füredi, E Bajtai, SN Sama… - Drug Resistance …, 2023 - Elsevier
Therapy resistance has long been considered to occur through the selection of pre-existing
clones equipped to survive and quickly regrow, or through the acquisition of mutations …

Redox signaling in drug-tolerant persister cells as an emerging therapeutic target

Z Zhang, Y Tan, C Huang, X Wei - EBioMedicine, 2023 - thelancet.com
Drug-tolerant persister (DTP) cells have attracted significant interest, given their
predominant role in treatment failure. In this respect, DTP cells reportedly survive after …

Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

M Le Compte, EC De La Hoz, S Peeters… - NPJ Precision …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, characterized
by a treatment-resistant and invasive nature. In line with these inherent aggressive …

Highly conserved homotrimer cavity formed by the SARS-CoV-2 spike glycoprotein: a novel binding site

U Kalathiya, M Padariya, M Mayordomo… - Journal of clinical …, 2020 - mdpi.com
An important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life
cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) …

Molecular imaging-guided sonodynamic therapy

J Guo, X Pan, C Wang, H Liu - Bioconjugate Chemistry, 2021 - ACS Publications
Low-intensity ultrasound-triggered sonodynamic therapy (SDT) is a promising noninvasive
therapeutic modality due to its strong tissue penetration ability. In recent years, with the …