Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

The rice blast fungus Magnaporthe oryzae causes a devastating disease that threatens
global rice (Oryza sativa) production. Despite intense study, the biology of plant tissue …

Necrosis in the tumor interior is a common feature of aggressive cancers that is associated
with poor clinical prognosis and the development of metastasis. How the necrotic core …

Cellular and non-cellular components of the tumor microenvironment (TME) are emerging
as key regulators of primary tumor progression, organ-specific metastasis, and therapeutic …

Smoking is associated with lung cancer and has a profound impact on tumor immunity.
Nicotine, the addictive and non-carcinogenic smoke component, influences various brain …

Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …

Tumor microenvironment-targeted therapies are emerging as promising treatment options
for different cancer types. Tumor-associated macrophages and microglia (TAMs) represent …

A high percentage of patients with brain metastases frequently develop neurocognitive
symptoms; however, understanding how brain metastasis co-opts the function of neuronal …