The emerging role of lncRNAs in osteoarthritis development and potential therapy

X Zhang, Q Liu, J Zhang, C Song, Z Han, J Wang… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis impairs the functions of various joints, such as knees, hips, hands and spine,
which causes pain, swelling, stiffness and reduced mobility in joints. Multiple factors …

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

L Zhang, H Zhang, Q Xie, H Feng, H Li, Z Li… - Frontiers in …, 2024 - frontiersin.org
Osteoarthritis (OA) is a degenerative disease of cartilage that affects the quality of life and
has increased in morbidity and mortality in recent years. Cartilage homeostasis and …

ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression

Y Tang, Y Liu, X Zhu, Y Chen, X Jiang, S Ding… - Iscience, 2023 - cell.com
Summary HS3ST3B1-IT1 was identified as a downregulated long noncoding RNA in
osteoarthritic cartilage. However, its roles and mechanisms in the pathogenesis of …

[HTML][HTML] High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression

TL Ho, YL Lai, CJ Hsu, CM Su, CH Tang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
High mobility group box-1 (HMGB1) is a driver of inflammation in various muscular diseases.
In a previous study, we determined that HMGB1 induced the atrophy of skeletal muscle by …

Identification of mitophagy‐related biomarkers in osteoarthritis

S Ruan, D Tang, Y Luo, H Song - Animal Models and …, 2024 - Wiley Online Library
Background Osteoarthritis (OA) is a common joint disease, and existing drugs cannot cure
OA, so there is an urgent need to identify new targets. Mitophagy plays an important role in …

(-)-Epicatechin regulates LOC107986454 by targeting the miR-143–3p/EZH2 axis to enhance the radiosensitivity of non-small cell lung cancer

M Huang, J Wang, H Zhou, Z Lv, T Li, M Liu, Y Lv… - The American Journal of …, 2024 - Elsevier
Background and objective Non-small cell lung cancer (NSCLC) is a pernicious tumor with
high incidence and mortality rates. The incidence rate of NSCLC increases with age and …