The extracellular matrix (ECM) performs many critical functions, one of which is to provide
structural and mechanical integrity, and many of the constituent proteins have clear …

Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

Many tumors, such as types of sarcoma and breast cancer, stiffen as they grow in a host
healthy tissue, while individual cancer cells are becoming softer. Tumor stiffening poses …

The mechanisms for maintaining oral cavity homeostasis are subject to the constant
influence of many environmental factors, including various chemicals and microorganisms …

Abstract Atomic Force Microscopy (AFM) nanoindentation is a powerful tool for the
mechanical nano-characterization of biological samples. However, the range of Young's …

Cancer progression is closely related to changes in the structure and mechanical properties
of the tumor microenvironment (TME). In many solid tumors, including pancreatic cancer, the …

Background Tumor microenvironment consists of the extracellular matrix (ECM), stromal
cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of …

Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also
accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is …

Simple Summary Atomic force microscopy (AFM) is a powerful technique that has been
pivotal to cancer research, but it has only recently been used to study tumor pathology at the …