Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Depression and inflammation fuel one another. Inflammation plays a key role in
depression's pathogenesis for a subset of depressed individuals; depression also primes …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

A major impediment to novel drug development has been the paucity of animal models that
accurately reflect symptoms of affective disorders. In animal models, prolonged social stress …

Objective To review the literature on psychological and biological findings on resilience (ie
the successful adaptation and swift recovery after experiencing life adversities) at the level of …

Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …

Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Food intake is regulated by 2 complementary drives: the homeostatic and hedonic
pathways. The homeostatic pathway controls energy balance by increasing the motivation to …