Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among
reproductive age women. Although its cardinal manifestations include hyperandrogenism …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

Sex hormones strongly influence body fat distribution and adipocyte differentiation.
Estrogens and testosterone differentially affect adipocyte physiology, but the importance of …

Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

Core body temperature changes across the ovulatory menstrual cycle, such that it is 0.3° C
to 0.7° C higher in the post-ovulatory luteal phase when progesterone is high compared with …

It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

That adult humans possess active brown adipose tissue potentially leads to a paradigm shift
in the understanding of human metabolism and of obesity. Adaptive adrenergic …

Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in
animals, conferring protection against diet-induced obesity and hypothermia through the …

Aging is associated with an overall loss of function at the level of the whole organism that
has origins in cellular deterioration. Most cellular components, including mitochondria …