The role of vitamins in neurodegenerative disease: An update

SN Rai, P Singh, HWM Steinbusch, E Vamanu… - Biomedicines, 2021 - mdpi.com
Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …

Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Dietary antioxidants and Parkinson's disease

HA Park, AC Ellis - Antioxidants, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder caused by the depletion of
dopaminergic neurons in the basal ganglia, the movement center of the brain …

[HTML][HTML] Disease model organism for Parkinson disease: Drosophila melanogaster

B Aryal, Y Lee - BMB reports, 2019 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
selective and progressive loss of dopaminergic neurons. Genetic and environmental risk …

Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease

P Saini, U Rudakou, E Yu, JA Ruskey, F Asayesh… - Neurobiology of …, 2021 - Elsevier
Rare mutations in genes originally discovered in multigenerational families have been
associated with increased risk of Parkinson's disease (PD). The involvement of rare variants …

Exploration of the Role of Vitamins in Preventing Neurodegenerative Diseases: Comprehensive Review on Preclinical and Clinical Findings

L Changkakoti, R Rajabalaya, SR David… - Current …, 2024 - benthamdirect.com
Neurodegenerative diseases (NDDs) are a multifaceted and heterogeneous group of
complex diseases. Unfortunately, a cure for these conditions has yet to be found, but there …

Therapeutic Potential of Polyscias fruticosa (L.) Harms Leaf Extract for Parkinson's Disease Treatment by Drosophila melanogaster Model

HT Ly, TTH Nguyen, VM Le, BT Lam… - Oxidative medicine …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized by progressive locomotive defects and loss of
dopaminergic neurons. Polyscias fruticosa leaves are used by Vietnamese as herbal …

[HTML][HTML] A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

FM Cerqueira, S von Stockum, M Giacomello, I Goliand… - Redox biology, 2020 - Elsevier
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-
cellular localization dependent on its farnesylation state. Despite UCH-L1′ s association …

Age-associated glia remodeling and mitochondrial dysfunction in neurodegeneration: antioxidant supplementation as a possible intervention

A Picca, E Ferri, R Calvani, HJ Coelho-Júnior… - Nutrients, 2022 - mdpi.com
Aging induces substantial remodeling of glia, including density, morphology, cytokine
expression, and phagocytic capacity. Alterations of glial cells, such as hypertrophy of …

[HTML][HTML] Progress in Parkinson's disease animal models of genetic defects: Characteristics and application

C Zhang, S Chen, X Li, Q Xu, Y Lin, F Lin… - Biomedicine & …, 2022 - Elsevier
Parkinson's disease (PD) is the second major progressive neurodegenerative disease,
which critically impacts patients' quality of life. Based on genetics, animal models of genetic …