Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Glutamine metabolism provides synergistic support for macrophage activation and elicitation
of desirable immune responses; however, the underlying mechanisms regulated by …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

A number of widespread and devastating chronic diseases, including atherosclerosis, type 2
diabetes, and Alzheimer's disease, have a pathophysiologically important inflammatory …

In terms of both phenotype and function, macrophages have remarkable heterogeneity,
which reflects the specialization of tissue-resident macrophages in microenvironments as …

Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …

Rationale: Differential activation of macrophages correlates closely with tumor progression,
and the epigenetic factor lysine demethylase 6B (KDM6B, previously named JMJD3) …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …