Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses

WJ Song, CKM Hui, JH Hull, SS Birring… - The Lancet …, 2021 - thelancet.com
Cough is one of the most common presenting symptoms of COVID-19, along with fever and
loss of taste and smell. Cough can persist for weeks or months after SARS-CoV-2 infection …

The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Rhinitis 2020: a practice parameter update

MS Dykewicz, DV Wallace, DJ Amrol… - Journal of Allergy and …, 2020 - Elsevier
This comprehensive practice parameter for allergic rhinitis (AR) and nonallergic rhinitis
(NAR) provides updated guidance on diagnosis, assessment, selection of monotherapy and …

Vagal afferent innervation of the airways in health and disease

SB Mazzone, BJ Undem - Physiological reviews, 2016 - journals.physiology.org
Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice

N Gannot, X Li, CD Phillips, AB Ozel… - Nature …, 2024 - nature.com
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …

[HTML][HTML] Chronic cough: new insights and future prospects

A Morice, P Dicpinigaitis, L McGarvey… - European Respiratory …, 2021 - Eur Respiratory Soc
Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

[HTML][HTML] A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

A Balestrini, V Joseph, M Dourado, RM Reese… - Journal of Experimental …, 2021 - rupress.org
Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …

[HTML][HTML] Is cough really necessary for TB transmission?

B Patterson, R Wood - Tuberculosis, 2019 - Elsevier
Cough has long been implicated in the production of infectious aerosol leading to
transmission of tuberculosis (TB). However, prevalence studies frequently identify …

Mechanisms and rationale for targeted therapies in refractory and unexplained chronic cough

SB Mazzone, L McGarvey - Clinical Pharmacology & …, 2021 - Wiley Online Library
Chronic cough, defined as a cough lasting> 8 weeks, is a common medical condition that
exerts a substantial physical, mental, and social burden on patients. A subset of patients with …

Cough hypersensitivity syndrome: a few more steps forward

WJ Song, AH Morice - Allergy, asthma & immunology …, 2017 - pmc.ncbi.nlm.nih.gov
Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it
can become hypersensitive. In fact, chronic cough is a significant medical problem with a …