XIAP as a multifaceted molecule in Cellular Signaling
XIAP, X-linked inhibitor of apoptosis protein, is a member of the inhibitor of apoptosis protein
(IAP) family known for its important conserved inhibitory effect on caspase activity. Since the …
(IAP) family known for its important conserved inhibitory effect on caspase activity. Since the …
The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
Alimentary tract (AT) mucositis can be a major problem for patients undergoing cancer
treatment. It has significant clinical and economic consequences and is a major factor that …
treatment. It has significant clinical and economic consequences and is a major factor that …
[HTML][HTML] PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma
CY Wei, MX Zhu, PF Zhang, XY Huang, JK Wan… - Journal of …, 2022 - Elsevier
Background & Aims Despite remarkable advances in treatment, most patients with
hepatocellular carcinoma (HCC) respond poorly to anti-programmed cell death 1 (anti-PD1) …
hepatocellular carcinoma (HCC) respond poorly to anti-programmed cell death 1 (anti-PD1) …
Curcumin suppresses the paclitaxel-induced nuclear factor-κB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
BB Aggarwal, S Shishodia, Y Takada, S Banerjee… - Clinical Cancer …, 2005 - AACR
Currently, there is no effective therapy for metastatic breast cancer after surgery, radiation,
and chemotherapy have been used against the primary tumor. Because curcumin …
and chemotherapy have been used against the primary tumor. Because curcumin …
MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways
MicroRNAs (miRNAs) as modulators of gene expression have been described to display
both tumor-promoting and tumor-suppressive functions. Although their role has been studied …
both tumor-promoting and tumor-suppressive functions. Although their role has been studied …
NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis
DK Biswas, Q Shi, S Baily, I Strickland… - Proceedings of the …, 2004 - National Acad Sciences
Lack of molecular targets in estrogen receptor-negative (ER-negative) breast cancer is a
major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in …
major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in …
Protein kinase C (PKC) family in cancer progression
J Koivunen, V Aaltonen, J Peltonen - Cancer letters, 2006 - Elsevier
PKC family consist of a number of serine-threonine kinases which are divided into three
groups based on their activating factors. PKCs have been linked to carcinogenesis since …
groups based on their activating factors. PKCs have been linked to carcinogenesis since …
The NF-κB/IκB signaling system: a molecular target in breast cancer therapy
JT Wu, JG Kral - Journal of Surgical Research, 2005 - Elsevier
The nuclear factor κB (NFκB) superfamily of eukaryotic transcription factors plays an
important role in carcinogenesis. NF-κB and its regulators are linked to various signal …
important role in carcinogenesis. NF-κB and its regulators are linked to various signal …
MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C ϵ (PKCϵ)
C Körner, I Keklikoglou, C Bender, A Wörner… - Journal of Biological …, 2013 - ASBMB
MicroRNAs post-transcriptionally regulate gene expression and thereby contribute to the
modulation of numerous complex and disease-relevant cellular phenotypes, including cell …
modulation of numerous complex and disease-relevant cellular phenotypes, including cell …
Linkage between EGFR family receptors and nuclear factor kappaB (NF‐κB) signaling in breast cancer
DK Biswas, JD Iglehart - Journal of cellular physiology, 2006 - Wiley Online Library
Abstract In the United States there are 225,000 new cases of invasive breast cancer
annually, and at least 50,000 women are diagnosed with ductal carcinoma in situ (DCIS) …
annually, and at least 50,000 women are diagnosed with ductal carcinoma in situ (DCIS) …