[HTML][HTML] Critical roles of PTPN family members regulated by non-coding RNAs in tumorigenesis and immunotherapy
X Tang, C Qi, H Zhou, Y Liu - Frontiers in oncology, 2022 - frontiersin.org
Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation state
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …
[HTML][HTML] Beyond the cell surface: targeting intracellular negative regulators to enhance T cell anti-tumor activity
P Sitaram, B Uyemura, S Malarkannan… - International Journal of …, 2019 - mdpi.com
It is well established that extracellular proteins that negatively regulate T cell function, such
as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death …
as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death …
[HTML][HTML] BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale
JWP Bracht, N Karachaliou, T Bivona, RB Lanman… - Cancers, 2019 - mdpi.com
BRAF V600 mutations have been found in 1–2% of non-small-cell lung cancer (NSCLC)
patients, with Food and Drug Administration (FDA) approved treatment of dabrafenib plus …
patients, with Food and Drug Administration (FDA) approved treatment of dabrafenib plus …
[HTML][HTML] PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis
W Kuang, X Wang, J Ding, J Li, M Ji, W Chen… - Frontiers in …, 2022 - frontiersin.org
Objective This study conducted a comprehensive analysis of the members of the PTPN
family and emphasized the key role of PTPN2 as a potential therapeutic target and …
family and emphasized the key role of PTPN2 as a potential therapeutic target and …
[HTML][HTML] Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia
X Wang, S Wu, L Sun, P Jin, J Zhang, W Liu, Z Zhan… - Scientific Reports, 2023 - nature.com
The non-receptor protein tyrosine phosphatases gene family (PTPNs) is involved in the
tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid …
tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid …
[HTML][HTML] Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma
C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …
The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation
S Chandel, A Manikandan, N Mehta… - Journal of cell …, 2021 - journals.biologists.com
Global and endothelial loss of PTP-PEST (also known as PTPN12) is associated with
impaired cardiovascular development and embryonic lethality. Although hypoxia is …
impaired cardiovascular development and embryonic lethality. Although hypoxia is …
[HTML][HTML] Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer
S Sarmasti Emami, A Ge, D Zhang, Y Hao… - International Journal of …, 2024 - mdpi.com
The Hippo pathway plays crucial roles in governing various biological processes during
tumorigenesis and metastasis. Within this pathway, upstream signaling stimuli activate a …
tumorigenesis and metastasis. Within this pathway, upstream signaling stimuli activate a …
[HTML][HTML] CD99–PTPN12 axis suppresses actin cytoskeleton-mediated dimerization of epidermal growth factor receptor
KJ Lee, Y Kim, MS Kim, HM Ju, B Choi, H Lee… - Cancers, 2020 - mdpi.com
Simple Summary The epidermal growth factor receptor (EGFR) is activated through growth
factor-dependent dimerization accompanied by functional reorganization of the actin …
factor-dependent dimerization accompanied by functional reorganization of the actin …
[HTML][HTML] From Tyrosine Kinases to Tyrosine Phosphatases: New Therapeutic Targets in Cancers and Beyond
Y Zhou, Z Yao, Y Lin, H Zhang - Pharmaceutics, 2024 - mdpi.com
Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) regulate the level
of tyrosine phosphorylation in proteins. PTKs are key enzymes that catalyze the transfer of …
of tyrosine phosphorylation in proteins. PTKs are key enzymes that catalyze the transfer of …