Alternatives of animal models for biomedical research: a comprehensive review of modern approaches

A Vashishat, P Patel, G Das Gupta… - Stem Cell Reviews and …, 2024 - Springer
Biomedical research has long relied on animal models to unravel the intricacies of human
physiology and pathology. However, concerns surrounding ethics, expenses, and inherent …

[HTML][HTML] The nematode Oscheius tipulae as a genetic model for programmed DNA elimination

TC Dockendorff, B Estrem, J Reed, JR Simmons… - Current Biology, 2022 - cell.com
Programmed DNA elimination (PDE) is a notable exception to the paradigm of genome
integrity. In metazoa, PDE often occurs coincident with germline to somatic cell …

[HTML][HTML] Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids

AJ Wolstenholme, EC Andersen… - Advances in …, 2024 - ncbi.nlm.nih.gov
The ascarids are a large group of parasitic nematodes that infect a wide range of animal
species. In humans, they cause neglected diseases of poverty; many animal parasites also …

[HTML][HTML] Small RNA pathways in the nematode Ascaris in the absence of piRNAs

MV Zagoskin, J Wang, AT Neff, GMB Veronezi… - Nature …, 2022 - nature.com
Small RNA pathways play key and diverse regulatory roles in C. elegans, but our
understanding of their conservation and contributions in other nematodes is limited. We …

Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes

JR Simmons, B Estrem, MV Zagoskin, R Oldridge… - Current Biology, 2024 - cell.com
An increasing number of metazoans undergo programmed DNA elimination (PDE), where a
significant amount of DNA is selectively lost from the somatic genome during development …

[HTML][HTML] Evaluation of the immunoprotective effects of eight recombinant proteins from Baylisascaris schroederi in mice model

L Xiong, L Chen, Y Chen, N Shen, R Hua, G Yang - Parasites & Vectors, 2023 - Springer
Background Baylisascaris schroederi is the most common and harmful intestinal parasitic
nematode of giant pandas, causing ascariasis. Although drug deworming is the main …

[HTML][HTML] Chromosome fusion and programmed DNA elimination shape karyotypes of parasitic nematodes

JR Simmons, B Estrem, MV Zagoskin, R Oldridge… - bioRxiv, 2023 - ncbi.nlm.nih.gov
A growing list of metazoans undergo programmed DNA elimination (PDE), where a
significant amount of DNA is selectively lost from the somatic genome during development …

Dual RNA-seq in filarial nematodes and Wolbachia endosymbionts using RNase H based ribosomal RNA depletion

LJ Cantin, V Gregory, LN Blum, JM Foster - Frontiers in Microbiology, 2024 - frontiersin.org
Lymphatic filariasis is caused by parasitic nematodes and is a leading cause of disability
worldwide. Many filarial worms contain the bacterium Wolbachia as an obligate …

Comparative genomics of Sarcoptes scabiei provide new insights into adaptation to permanent parasitism and within‐host species divergence

J Xu, Q Wang, S Wang, W Huang, Y Xie… - Transboundary and …, 2022 - Wiley Online Library
Sarcoptes scabiei is the causative agent of a highly contagious skin disease in humans and
more than 100 mammals. Here, we reported the first chromosome‐level reference genome …

[HTML][HTML] A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway

J Xu, X Gu, Y Xie, R He, J Xu, L Xiong, X Peng… - Parasites & …, 2022 - Springer
Abstract Background Giant pandas (Ailuropoda melanoleuca) are the obligate host of the
parasitic roundworm Baylisascaris schroederi. The infection of giant pandas with B …