Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …

DNA methylation is currently one of the most promising age-predictive biomarkers. Many
studies have reported DNA methylation-based age predictive models, but most of these are …

Reduced brain-derived neurotrophic factor (BDNF) may underlie age-related synaptic loss,
in turn contributing to cerebral atrophy, cognitive decline, and increased risk for psychiatric …

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been
postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and …

Aging is associated with reduced brain volume, altered neural activity, and neuronal atrophy
in cortical-like structures, comprising the frontal cortex and hippocampus, together …

Recent advancements in technology have enabled researchers to probe the brain with the
greater region, cell, and receptor specificity. These developments have allowed for a more …

As a member of the neurotrophic factor family, brain derived neurotrophic factor (BDNF)
plays an important role in the survival and differentiation of neurons. The aim of our work …

The accelerated aging hypothesis of schizophrenia posits that physiological changes
throughout the body that are associated with normal aging occur at an earlier age in …