Nucleotide sugars in chemistry and biology

S Mikkola - Molecules, 2020 - mdpi.com
Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

Strategies for automated enzymatic glycan synthesis (AEGS)

KP Hussnaetter, P Palm, A Pich, M Franzreb… - Biotechnology …, 2023 - Elsevier
Glycans are the most abundant biopolymers on earth and are constituents of glycoproteins,
glycolipids, and proteoglycans with multiple biological functions. The availability of different …

Facile synthesis of sugar nucleotides from common sugars by the cascade conversion strategy

S Wang, J Zhang, F Wei, W Li… - Journal of the American …, 2022 - ACS Publications
Sugar nucleotides are essential glycosylation donors in the carbohydrate metabolism.
Naturally, most sugar nucleotides are derived from a limited number of common sugar …

Enzyme cascades for the synthesis of nucleotide sugars: Updates to recent production strategies

H Frohnmeyer, L Elling - Carbohydrate Research, 2023 - Elsevier
Nucleotide sugars play an elementary role in nature as building blocks of glycans,
polysaccharides, and glycoconjugates used in the pharmaceutical, cosmetics, and food …

Biological strategies for oligo/polysaccharide synthesis: Biocatalyst and microbial cell factory

L Zhao, Z Ma, J Yin, G Shi, Z Ding - Carbohydrate Polymers, 2021 - Elsevier
Oligosaccharides and polysaccharides constitute the principal components of
carbohydrates, which are important biomacromolecules that demonstrate considerable …

Biocatalytic approaches to building blocks for enzymatic and chemical glycan synthesis

JP Dolan, SC Cosgrove, GJ Miller - JACS Au, 2022 - ACS Publications
While the field of biocatalysis has bloomed over the past 20–30 years, advances in the
understanding and improvement of carbohydrate-active enzymes, in particular, the sugar …

Computational Insight into Intraspecies Distinctions in Pseudoalteromonas distincta: Carotenoid-like Synthesis Traits and Genomic Heterogeneity

L Balabanova, O Nedashkovskaya… - International Journal of …, 2023 - mdpi.com
Advances in the computational annotation of genomes and the predictive potential of current
metabolic models, based on more than thousands of experimental phenotypes, allow them …

Substrate promiscuities of a bacterial galactokinase and a glucose-1-phosphate uridyltransferase enable xylose salvaging

JM Shi, TT Wu, H Zhou, YY Zhang, L Liu… - Green …, 2022 - pubs.rsc.org
Galactokinases (GalKs) are structurally conserved proteins that exist in all domains of life.
These enzymes catalyse the transfer of a phosphate group from adenosine triphosphate …

Synthesis of selected unnatural sugar nucleotides for biotechnological applications

M Qiao, B Li, Y Ji, L Lin, R Linhardt… - Critical reviews in …, 2021 - Taylor & Francis
Sugar nucleotides are the principal building blocks for the synthesis of most complex
carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine …

Production of glycopeptide derivatives for exploring substrate specificity of human OGA toward sugar moiety

S Li, J Wang, L Zang, H Zhu, J Guo, J Zhang… - Frontiers in …, 2019 - frontiersin.org
O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine
(GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key …