The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

During the last decade, there have been substantial advances in the identification and
characterization of DNA sequence variants associated with individual predisposition to type …

Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority
populations are disproportionately affected by diabetes and obesity-related complications …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

Adipose development is regulated by a series of complex processes, and non-coding RNAs
(ncRNAs), including circular RNAs (circRNAs), play important roles in regulating …

Introduction There are known disparities in diabetes complications by race and ethnicity.
Although diabetes subgroups may contribute to differential risk, little is known about how …

OBJECTIVE We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention,
incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is …

Context Pancreatic steatosis leading to beta-cell failure might be involved in type 2 diabetes
(T2D) pathogenesis. Objective We hypothesized that the genetic background modulates the …

Context Type 2 diabetes mellitus (T2DM) and cancer share a variety of risk factors and
pathophysiological features. It is becoming increasingly accepted that the 2 diseases are …