The structure and function of the barrier layers restricting the free diffusion of substances
between the central nervous system (brain and spinal cord) and the systemic circulation is of …

Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular
pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

The blood-retina barrier (BRB) is composed of both an inner and an outer barrier. The outer
BRB refers to the barrier formed at the retinal pigment epithelial (RPE) cell layer and …

ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the
assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In …

Tight junctions are the most apical component of the epithelial junctional complex and are
crucial for the formation and functioning of epithelial and endothelial barriers. They regulate …

The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier by regulating the
movement of solutes between the fenestrated capillaries of the choroid and the …

Epithelial cells form a barrier against the environment, but are also required for the regulated
exchange of molecules between an organism and its surroundings. Epithelial cells are …

The Hippo pathway regulates the size of organs by controlling two opposing processes:
proliferation and apoptosis. YAP2 (Yes kinase-associated protein 2), one of the three …

Abstract ZO-1, ZO-2, and ZO-3 are closely related scaffolding proteins that link tight junction
(TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin …