The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

This e-book will review special features of the cerebral circulation and how they contribute to
the physiology of the brain. It describes structural and functional properties of the cerebral …

Abstract Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant
neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two …

The skeletal dysplasias (osteochondrodysplasias) are a heterogeneous group of more than
350 disorders frequently associated with orthopedic complications and varying degrees of …

Abstract TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase
activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether …

The spondylometaphyseal dysplasias (SMDs) are a group of short-stature disorders
distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones …

Tissue size, shape, and organization reflect individual cell behaviors such as proliferation,
shape change, and movement. Evidence suggests that mechanical signals operate in …

The alpha-kinase family represents a class of atypical protein kinases that display little
sequence similarity to conventional protein kinases. Early studies on myosin heavy chain …

Mechanosensitive channels (MSCs) play an important role in how cells transduce
mechanical stimuli into electrical or chemical signals, which provides an interventional …

Transient Receptor Potential (TRP) channels modulate intracellular Ca2+ concentrations,
controlling critical cytosolic and nuclear events that are involved in the initiation and …