New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a
whole universe of modifications to their canonical chemical structure, which can in various …
whole universe of modifications to their canonical chemical structure, which can in various …
Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H
Y Masaki, A Tabira, S Hattori, S Wakatsuki… - Organic & Biomolecular …, 2022 - pubs.rsc.org
RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs).
Although various chemical modifications have been developed to regulate RNase H …
Although various chemical modifications have been developed to regulate RNase H …
Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C, 5′-C-methylene-bridged nucleic acid (4′, 5′-BNA)
T Yamaguchi, C Yamamoto, M Horiba… - Bioorganic & Medicinal …, 2021 - Elsevier
We describe herein the design and synthesis of 4′-C, 5′-C-methylene-bridged nucleic
acid (4′, 5′-BNA), a novel artificial nucleic acid with the torsion angle γ in a non …
acid (4′, 5′-BNA), a novel artificial nucleic acid with the torsion angle γ in a non …
Mesyl phosphoramidate oligonucleotides: a new promising type of antisense agents
DA Stetsenko - Handbook of chemical Biology of nucleic acids, 2023 - Springer
This chapter provides an overview of mesyl phosphoramidate oligonucleotides (μ-
oligonucleotides), which incorporate mesyl phosphoramidate groups (MsPA, or μ) instead of …
oligonucleotides), which incorporate mesyl phosphoramidate groups (MsPA, or μ) instead of …
Recent developments of artificial functional oligo nucleic acids
Y Moai, T Kodama - Tetrahedron Letters, 2020 - Elsevier
Nucleic acid can bind to a complementary nucleic acid based on its sequence information.
Therefore, nucleic acids can be applied to technology development related to detection and …
Therefore, nucleic acids can be applied to technology development related to detection and …