Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

Neuromelanin-sensitive MRI (NM-MRI) purports to detect the content of neuromelanin (NM),
a product of dopamine metabolism that accumulates with age in dopamine neurons of the …

Although aging is associated with clear declines in physical and cognitive processes,
emotional functioning fares relatively well. Consistent with this behavioral profile, two core …

For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …