Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
Small-cell lung cancer
CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …
[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Mechanisms of small cell lung cancer metastasis
J Ko, MM Winslow, J Sage - EMBO molecular medicine, 2021 - embopress.org
Metastasis is a major cause of morbidity and mortality in cancer patients. However, the
molecular and cellular mechanisms underlying the ability of cancer cells to metastasize …
molecular and cellular mechanisms underlying the ability of cancer cells to metastasize …
Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states
Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …
KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming
Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …
[HTML][HTML] New approaches to SCLC therapy: from the laboratory to the clinic
JT Poirier, J George, TK Owonikoko, A Berns… - Journal of Thoracic …, 2020 - Elsevier
The outcomes of patients with SCLC have not yet been substantially impacted by the
revolution in precision oncology, primarily owing to a paucity of genetic alterations in …
revolution in precision oncology, primarily owing to a paucity of genetic alterations in …
[HTML][HTML] Cancer: a mirrored room between tumor bulk and tumor microenvironment
P Hernández-Camarero, E López-Ruiz… - Journal of Experimental …, 2021 - Springer
It has been well documented that the tumor microenvironment (TME) plays a key role in the
promotion of drug resistance, the support of tumor progression, invasiveness, metastasis …
promotion of drug resistance, the support of tumor progression, invasiveness, metastasis …
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …
[HTML][HTML] Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …