Mechanical regulation of mesenchymal stem cell differentiation

AJ Steward, DJ Kelly - Journal of anatomy, 2015 - Wiley Online Library
Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Mechanobiology of mesenchymal stem cells: perspective into mechanical induction of MSC fate

J Hao, Y Zhang, D Jing, Y Shen, G Tang, S Huang… - Acta biomaterialia, 2015 - Elsevier
Bone marrow-derived mesenchymal stem and stromal cells (MSCs) are promising
candidates for cell-based therapies in diverse conditions including tissue engineering …

Dental pulp stem cell mechanoresponsiveness: effects of mechanical stimuli on dental pulp stem cell behavior

M Marrelli, B Codispoti, RM Shelton… - Frontiers in …, 2018 - frontiersin.org
Dental pulp is known to be an accessible and important source of multipotent mesenchymal
progenitor cells termed dental pulp stem cells (DPSCs). DPSCs can differentiate into …

An automated 3D-printed perfusion bioreactor combinable with pulsed electromagnetic field stimulators for bone tissue investigations

S Gabetti, B Masante, A Cochis, G Putame… - Scientific Reports, 2022 - nature.com
In bone tissue engineering research, bioreactors designed for replicating the main features
of the complex native environment represent powerful investigation tools. Moreover, when …

Progress in the mechanical modulation of cell functions in tissue engineering

K Dey, E Roca, G Ramorino, L Sartore - Biomaterials Science, 2020 - pubs.rsc.org
In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …

Integrins in the regulation of mesenchymal stem cell differentiation by mechanical signals

L Wang, F Zheng, R Song, L Zhuang, M Yang… - Stem Cell Reviews and …, 2022 - Springer
Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a
chemical response. Integrins are involved in the mechanotransduction from inside to outside …

3D bioprinting: A powerful tool to leverage tissue engineering and microbial systems

E Saygili, AA Dogan-Gurbuz, O Yesil-Celiktas, MS Draz - Bioprinting, 2020 - Elsevier
Bioprinting covers the precise deposition of cells, biological scaffolds and growth factors to
produce desired tissue models. The main focus of bioprinting is the creation of functional …

Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors

S Sart, SN Agathos, Y Li, T Ma - Biotechnology journal, 2016 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) have emerged as an important cell type in cell
therapy and tissue engineering. In these applications, maintaining the therapeutic properties …

Hydrostatic pressure regulates the volume, aggregation and chondrogenic differentiation of bone marrow derived stromal cells

P Aprile, DJ Kelly - Frontiers in Bioengineering and Biotechnology, 2021 - frontiersin.org
The limited ability of articular cartilage to self-repair has motivated the development of tissue
engineering strategies that aim to harness the regenerative potential of mesenchymal …

Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells

SF Carroll, CT Buckley, DJ Kelly - Frontiers in Bioengineering and …, 2017 - frontiersin.org
Successfully regenerating damaged or diseased bone and other joint tissues will require a
detailed understanding of how joint specific environmental cues regulate the fate of …