[HTML][HTML] Sugar addiction: from evolution to revolution
The obesity epidemic has been widely publicized in the media worldwide. Investigators at all
levels have been looking for factors that have contributed to the development of this …
levels have been looking for factors that have contributed to the development of this …
Vigor, effort-related aspects of motivation and anhedonia
MT Treadway, JD Salamone - Anhedonia: preclinical, translational, and …, 2022 - Springer
In this chapter we provide an overview of the pharmacological and circuit mechanisms that
determine the willingness to expend effort in pursuit of rewards. A particular focus will be on …
determine the willingness to expend effort in pursuit of rewards. A particular focus will be on …
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …
including feeding, but less is known about how these circuits may interact. In this study, we …
A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
Chronic stress causes dysregulations of mood and energy homeostasis, but the
neurocircuitry underlying these alterations remain to be fully elucidated. Here we …
neurocircuitry underlying these alterations remain to be fully elucidated. Here we …
A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger
X Cui, Q Tong, H Xu, C Xie, L Xiao - Progress in Neurobiology, 2023 - Elsevier
Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …
[HTML][HTML] GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
R Hanssen, AC Kretschmer, L Rigoux, K Albus… - Molecular …, 2021 - Elsevier
Objective To regulate food intake, our brain constantly integrates external cues, such as the
incentive value of a potential food reward, with internal state signals, such as hunger …
incentive value of a potential food reward, with internal state signals, such as hunger …
Modulating dopamine signaling and behavior with chemogenetics: concepts, progress, and challenges
AH Runegaard, CM Fitzpatrick, DPD Woldbye… - Pharmacological …, 2019 - ASPET
For more than 60 years, dopamine (DA) has been known as a critical modulatory
neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions …
neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions …
Zona incerta dopamine neurons encode motivational vigor in food seeking
Energy deprivation triggers food seeking to ensure homeostatic consumption, but the neural
coding of motivational vigor in food seeking during physical hunger remains unknown. Here …
coding of motivational vigor in food seeking during physical hunger remains unknown. Here …
Oxytocin receptor-expressing neurons in the paraventricular thalamus regulate feeding motivation through excitatory projections to the nucleus accumbens core
Oxytocin receptors (OTR) have been found in the paraventricular thalamus (PVT) for the
regulation of feeding and maternal behaviors. However, the functional projections of OTR …
regulation of feeding and maternal behaviors. However, the functional projections of OTR …
Somatodendritic release of cholecystokinin potentiates GABAergic synapses onto ventral tegmental area dopamine cells
VM Damonte, MB Pomrenze, CE Manning, C Casper… - Biological …, 2023 - Elsevier
Background Neuropeptides are contained in nearly every neuron in the central nervous
system and can be released not only from nerve terminals but also from somatodendritic …
system and can be released not only from nerve terminals but also from somatodendritic …