Amino acids play several critical roles in plants, from providing the building blocks of
proteins to being essential metabolites interacting with many branches of metabolism. They …

Although amino acids are critical for all forms of life, only proteogenic amino acids that
humans and animals cannot synthesize de novo and therefore must acquire in their diets …

An introduction to the mathematical concepts and techniques needed for the construction
and analysis of models in molecular systems biology. Systems techniques are integral to …

Pathways regulating threonine, methionine and isoleucine metabolism are very efficiently
interconnected in plants. As both threonine and methionine serve as substrates for …

Drought being a yield limiting factor has become a major threat to international food security.
It is a complex trait and drought tolerance response is carried out by various genes …

Recent data suggest that the majority of proteins bind specific metabolites, and that such
interactions are relevant to metabolic and gene regulation,,. However, there are no methods …

Kinetic models are critical to predict the dynamic behaviour of metabolic networks.
Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting …

Plants can assimilate inorganic nitrogen (N) sources to organic N such as amino acids. N is
the most important of the mineral nutrients required by plants and its metabolism is tightly …

An extension of directed evolution strategies to genome-wide variations increases the
chance of obtaining metabolite-overproducing microbes. However, a general high …

Construction of metabolic and regulatory pathways from proteomic data can contextualize
the large‐scale data within the overall physiological scheme of an organism. It is an efficient …