Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

Identification of novel neurohormones that regulate the reproductive axis is essential for the
progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) …

Until recently, any neuropeptide that directly inhibits gonadotropin secretion had not been
identified. We recently identified a novel hypothalamic dodecapeptide that directly inhibits …

Testicular heating suppresses spermatogenesis which is marked by germ cell loss via
apoptotic pathways. Recently, it is reported that autophagy also can be induced by heat …

Mature sperm are the product of a precisely regulated developmental sequence in which
germ cell proliferation, differentiation, self‐renewal and apoptosis are carefully controlled …

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) was intensely expressed in
mitochondria in the midpiece of human spermatozoa by immunostaining with anti-PHGPx …

Identification of novel neurohormones that play important roles in the regulation of pituitary
function is essential for the progress of neurobiology. The decapeptide gonadotropin …

Short-term exposure (43 C for 15 min) of the rat testis to mild heat results within 6 h in stage-
and cell-specific activation of germ cell apoptosis. Initiation of apoptosis was preceded by a …

Programmed cell death or apoptosis is a widespread biological phenomenon. Apoptosis is
characterized by typical cell features such as membrane blebbing, chromatin condensation …

While it is well known that serious illness and inflammation reduce male fertility, the
mechanisms involved are poorly understood. In adult male rats, a single injection of …