Bone remodeling: an operational process ensuring survival and bone mechanical competence

S Bolamperti, I Villa, A Rubinacci - Bone Research, 2022 - nature.com
Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

T cell receptor (TCR) signaling in health and disease

K Shah, A Al-Haidari, J Sun, JU Kazi - Signal transduction and targeted …, 2021 - nature.com
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

The role of oxidative stress and antioxidant balance in pregnancy

T Hussain, G Murtaza, E Metwally… - Mediators of …, 2021 - Wiley Online Library
It has been widely known that oxidative stress disrupts the balance between reactive oxygen
species (ROS) and the antioxidant system in the body. During pregnancy, the physiological …

Targeting TNF-α for COVID-19: recent advanced and controversies

Y Guo, K Hu, Y Li, C Lu, K Ling, C Cai… - Frontiers in public …, 2022 - frontiersin.org
Recent advances in the pathophysiologic understanding of coronavirus disease 2019
(COVID-19) suggests that cytokine release syndrome (CRS) has an association with the …

[HTML][HTML] Inflammation as a central mechanism in Alzheimer's disease

JW Kinney, SM Bemiller, AS Murtishaw… - Alzheimer's & Dementia …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke

SB Chidambaram, AG Rathipriya, AM Mahalakshmi… - Cells, 2022 - mdpi.com
Recent research on the gut microbiome has revealed the influence of gut microbiota (GM)
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …

microRNA dysregulation in neurodegenerative diseases: A systematic review

CA Juźwik, SS Drake, Y Zhang, N Paradis-Isler… - Progress in …, 2019 - Elsevier
While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

A novel and compact review on the role of oxidative stress in female reproduction

J Lu, Z Wang, J Cao, Y Chen, Y Dong - Reproductive Biology and …, 2018 - Springer
In recent years, the study of oxidative stress (OS) has become increasingly popular. In
particular, the role of OS on female fertility is very important and has been focused on …

Inflammasomes: mechanism of assembly, regulation and signalling

P Broz, VM Dixit - Nature Reviews Immunology, 2016 - nature.com
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …