Diabetes and aortic aneurysm: current state of the art
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …
curative treatment available relies on surgical approaches; drug-based therapies are …
Diabetes mellitus: is it protective against aneurysm? A narrative review
Objectives: In the course of extensive clinical aortic surgery, we noticed that the aorta was
quite thick and fibrotic in diabetic patients. We thought the diabetic aortic aorta might be …
quite thick and fibrotic in diabetic patients. We thought the diabetic aortic aorta might be …
Association between metformin prescription and growth rates of abdominal aortic aneurysms
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …
[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …
NLRP3 (nucleotide oligomerization domain–like receptor family, pyrin domain containing 3)–caspase-1 inflammasome degrades contractile proteins: implications for …
D Wu, P Ren, Y Zheng, L Zhang, G Xu… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Increasing evidence suggests that contractile dysfunction in smooth muscle cells
(SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and …
(SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and …
[HTML][HTML] Editor's Choice–Association between metformin prescription and abdominal aortic aneurysm growth and clinical events: a systematic review and meta …
Objective A meta-analysis of the association between metformin prescription and abdominal
aortic aneurysm (AAA) growth and events (rupture or surgical repair) was performed …
aortic aneurysm (AAA) growth and events (rupture or surgical repair) was performed …
Exploring the correlation and protective role of diabetes mellitus in aortic aneurysm disease
D Arun, W Munir, LV Schmitt, R Vyas… - Frontiers in …, 2021 - frontiersin.org
Introduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular
and peripheral vascular disease, as the abnormal metabolic state increases the risk for …
and peripheral vascular disease, as the abnormal metabolic state increases the risk for …
Importance of NLRP3 inflammasome in abdominal aortic aneurysms
Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease,
which particularly affects older people. Nucleotide-binding oligomerization domain-like …
which particularly affects older people. Nucleotide-binding oligomerization domain-like …
[HTML][HTML] Metformin prescription associated with reduced abdominal aortic aneurysm growth rate and reduced chemokine expression in a Swedish cohort
J Unosson, D Wågsäter, N Bjarnegård… - Annals of vascular …, 2021 - Elsevier
Background Recent reports suggest that the negative association between diabetes mellitus
and abdominal aortic aneurysm (AAA) may be driven by metformin, the world's most …
and abdominal aortic aneurysm (AAA) may be driven by metformin, the world's most …
Metformin prescription and aortic aneurysm: systematic review and meta-analysis
Objective To assess the association of metformin prescription with the risk of aortic
aneurysm, aortic aneurysm events and the enlargement of abdominal aortic aneurysm …
aneurysm, aortic aneurysm events and the enlargement of abdominal aortic aneurysm …