Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

Cancer is the primary cause of human mortality in most countries. This tendency has
increased as various medical therapeutics have advanced, which suggests that we cannot …

Hypoxia and acidity provide microenvironment for selection under evolutionary pressure
and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of …

Helmut Sies established the concept of oxidative stress in 1985. However, it took some time
to introduce this concept into pathology, where investigators count on formalin‐fixed paraffin …

Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively
following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated …

The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma,
with 30%–40% mesotheliomas showing NF2 inactivation. NF2 encodes merlin, a member of …

Asbestos is still a social burden worldwide as a carcinogen causing malignant
mesothelioma. Whereas recent studies suggest that local iron reduction is a preventive …

Malignant mesothelioma is an aggressive neoplasm for which effective treatments are
lacking. We often encounter mesothelioma cases with a profound desmoplastic reaction …

Any independent life requires iron to survive. Whereas iron deficiency causes oxygen
insufficiency, excess iron is a risk for cancer, generating a double-edged sword. Iron …

Simple Summary Tumor immune microenvironment is an important structural component of
malignant pleural mesothelioma that contributes to disease growth support and progression …