Introduction Meta-analyses implicate immune dysfunction in depression confirming
increased levels of circulating immune proteins (eg, cytokines) in depression cases …

Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with
increased plasma levels of pro-inflammatory mediators targeting all tissues including the …

In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

There is a vital need to understand mechanisms contributing to susceptibility to depression
to improve treatments for the 11% of Americans who currently suffer from this debilitating …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Major depressive disorder (MDD) is a common, severe and disabling neuropsychiatric
disorder with a heterogenous etiology. Among the most widely recognized etiological …

Background: We have investigated the distribution of the Th1, Th2 and Th17 subsets in
circulating CD4+ T lymphocytes and their naïve (TN), effector (TE), central (TCM) and …

Depression is a common and recurrent mental illness with a complicated etiology, but the
specific pathogenesis is not clear. Breast cancer increases susceptibility to depression …

Depression is one of the most common neuropsychiatric disorders in the world. While
conventional pharmaceutical therapy targets monoaminergic pathway dysfunction, it has not …

Depression is a highly prevalent disorder of the central nervous system. The
neuropsychiatric symptoms of clinical depression are persistent and include fatigue …