Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …

[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

W Meng, C He, Y Hao, L Wang, L Li, G Zhu - Drug delivery, 2020 - Taylor & Francis
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are
nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer

S Dong, X Liu, Y Bi, Y Wang, A Antony, DY Lee… - Nature …, 2023 - nature.com
The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy

JN Hao, K Ge, G Chen, B Dai, Y Li - Chemical Society Reviews, 2023 - pubs.rsc.org
Chemodynamic therapy (CDT) is a newly developed cancer-therapeutic modality that kills
cancer cells by the highly toxic hydroxyl radical (˙ OH) generated from the in situ triggered …

Overview and update on extracellular vesicles: considerations on exosomes and their application in modern medicine

MA Di Bella - Biology, 2022 - mdpi.com
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized
particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular …

Responsive exosome nano‐bioconjugates for synergistic cancer therapy

W Nie, G Wu, J Zhang, LL Huang, J Ding… - Angewandte Chemie …, 2020 - Wiley Online Library
Exosomes hold great potential in therapeutic development. However, native exosomes
usually induce insufficient effects in vivo and simply act as drug delivery vehicles. Herein, we …

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

S Dallavalle, V Dobričić, L Lazzarato, E Gazzano… - Drug Resistance …, 2020 - Elsevier
Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …