Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of
inflammatory disorders, cardiometabolic and neurological diseases, and several forms of …

Abstract Background Extracellular vesicles (EVs) are produced and secreted from most cells
of the body and can be recovered in biological fluids. Although there has been extensive …

Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate
cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective …

Dysregulated lipid metabolism is a prominent feature of prostate cancer that is driven by
androgen receptor (AR) signaling. Here we used quantitative mass spectrometry to define …