Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

In recent years, there has been significant progress in the use of Cre-loxP technology for
conditional gene expression in the inner ear. Here, we introduce the basic concepts of this …

The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner
ear generally leads to permanent hearing loss in humans. Here, we present that …

Self-renewal and proliferation of nephron progenitor cells and the decision to initiate
nephrogenesis are crucial events directing kidney development. Despite recent …

Sensorineural hearing loss is caused by the loss of sensory hair cells and neurons of the
inner ear. Once lost, these cell types are not replaced. Two genes expressed in the …

We review the development and evolution of the ear neurosensory cells, the aggregation of
neurosensory cells into an otic placode, the evolution of novel neurosensory structures …

The vertebrate inner ear is a precision sensory organ, acting as both a microphone to
receive sound and an accelerometer to detect gravity and motion. It consists of a series of …

Neuroblastoma (NB) is a childhood tumor that arises from the sympathoadrenal lineage.
MYCN amplification is the most reliable marker for poor prognosis and MYCN …

The mechanosensory hair cells of the inner ear have emerged as one of the primary models
for studying the development of planar polarity in vertebrates. Planar polarity is the polarized …

Proper tissue development requires strict coordination of proliferation, growth, and
differentiation. Strict coordination is particularly important for the auditory sensory epithelium …