Multi-omics integration in the age of million single-cell data
An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
[HTML][HTML] Hematopoietic stem cell metabolism during development and aging
Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …
Mapping human haematopoietic stem cells from haemogenic endothelium to birth
The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …
Lifelong multilineage contribution by embryonic-born blood progenitors
Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
Integrative bulk and single-cell profiling of premanufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy
The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough
in clinical oncology, yet both between-and within-patient differences in autologously derived …
in clinical oncology, yet both between-and within-patient differences in autologously derived …
[HTML][HTML] Mapping transcriptomic vector fields of single cells
Summary Single-cell (sc) RNA-seq, together with RNA velocity and metabolic labeling,
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
JJ Ghersi, G Baldissera, J Hintzen, SA Luff… - Nature Cell …, 2023 - nature.com
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …
[HTML][HTML] Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo
T Dignum, B Varnum-Finney, SR Srivatsan, S Dozono… - Cell reports, 2021 - cell.com
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …
scDART: integrating unmatched scRNA-seq and scATAC-seq data and learning cross-modality relationship simultaneously
It is a challenging task to integrate scRNA-seq and scATAC-seq data obtained from different
batches. Existing methods tend to use a pre-defined gene activity matrix to convert the …
batches. Existing methods tend to use a pre-defined gene activity matrix to convert the …