More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

The sarcomere is an exquisitely designed apparatus that is capable of generating force,
which in the case of the heart results in the pumping of blood throughout the body. At the …

Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders,
including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although …

G protein-coupled receptors signal through a variety of mechanisms that impact cardiac
function, including contractility and hypertrophy. G protein–dependent and G protein …

The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of
demands. Given the heart pumps without rest for decades its efficiency is particularly …

Background—Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for≈
50% of all cases of HF and currently has no effective treatment. Diastolic dysfunction …

Rationale: Cardiac myosin-binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-
282, and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest …

Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …

Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filaments of the
sarcomere. Understanding the structural and functional role of cMyBP-C in the heart is …

Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …