Analyzing high-dimensional cytometry data using FlowSOM
The dimensionality of cytometry data has strongly increased in the last decade, and in many
situations the traditional manual downstream analysis becomes insufficient. The field is …
situations the traditional manual downstream analysis becomes insufficient. The field is …
Immune cell profiling in atherosclerosis: role in research and precision medicine
DM Fernandez, C Giannarelli - Nature Reviews Cardiology, 2022 - nature.com
Inflammation is intimately involved at all stages of atherosclerosis and remains a substantial
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has
demonstrated potential for treatment of various cancers,,,,,–. However, little is known about …
demonstrated potential for treatment of various cancers,,,,,–. However, little is known about …
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
[HTML][HTML] Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
B Chen, S Cherie'R, ET McKinley, AJ Simmons… - Cell, 2021 - cell.com
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)
Initially, children were thought to be spared from disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …
Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy
B-cell maturation antigen (BCMA) is a prominent tumor-associated target for chimeric
antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case …
antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case …
[HTML][HTML] Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue
Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …
Severe COVID-19 is marked by a dysregulated myeloid cell compartment
J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …
infection, however, a subset of patients progress to severe disease and respiratory failure …