The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …
subjected to DNA methylation and various histone modifications. Such a 'language'of …
Determining cell type abundance and expression from bulk tissues with digital cytometry
Single-cell RNA-sequencing has emerged as a powerful technique for characterizing
cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be …
cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be …
Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma
D Ennishi, A Jiang, M Boyle, B Collinge… - Journal of Clinical …, 2019 - ascopubs.org
Purpose High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
(HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to …
(HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to …
Follicular lymphoma
A Carbone, S Roulland, A Gloghini, A Younes… - Nature reviews Disease …, 2019 - nature.com
Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition
D Ennishi, K Takata, W Béguelin, G Duns, A Mottok… - Cancer discovery, 2019 - AACR
We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with
diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired …
diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired …
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7 …
YH Huang, K Cai, PP Xu, L Wang, CX Huang… - … and Targeted Therapy, 2021 - nature.com
Epigenetic alterations play an important role in tumor progression of diffuse large B-cell
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …
Genetics of diffuse large B-cell lymphoma
L Pasqualucci, R Dalla-Favera - Blood, The Journal of the …, 2018 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
Role of HDACs in normal and malignant hematopoiesis
P Wang, Z Wang, J Liu - Molecular cancer, 2020 - Springer
Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …
gene expression at each stage of development, and epigenetic regulators play a vital role …
Genetic alterations and their clinical implications in DLBCL
Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …
variations in gene expression profiles and genetic alterations, which lead to substantial …