Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …

Necroptosis is a caspase-independent form of cell death that is triggered by activation of the
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …

A properly mounted immune response is indispensable for recognizing and eliminating
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing
intracellular components that can trigger an innate immune response. Toll-like receptor 3 …