[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Wnt signaling: a promising target for osteoarthritis therapy
Y Wang, X Fan, L Xing, F Tian - Cell Communication and Signaling, 2019 - Springer
Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …
Wnt/β-catenin signaling in osteoarthritis and in other forms of arthritis
Y Zhou, T Wang, JL Hamilton, D Chen - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …
[HTML][HTML] Wnt signaling in cartilage development and diseases: lessons from animal studies
Y Usami, AT Gunawardena, M Iwamoto… - Laboratory …, 2016 - Elsevier
Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …
postnatal stages but also serves to provide smooth movement of skeletons throughout life …
[HTML][HTML] Signaling pathways in cartilage repair
E Mariani, L Pulsatelli, A Facchini - International journal of molecular …, 2014 - mdpi.com
In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
[HTML][HTML] Correlation between gene expression and osteoarthritis progression in human
Osteoarthritis (OA) is a multifactorial disease characterized by gradual degradation of joint
cartilage. This study aimed to quantify major pathogenetic factors during OA progression in …
cartilage. This study aimed to quantify major pathogenetic factors during OA progression in …
Dkk‐1–Mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis in mice
T Funck‐Brentano, W Bouaziz, C Marty… - Arthritis & …, 2014 - Wiley Online Library
Objective Wnt signaling is a master regulator of joint homeostasis, but its role in
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …
[HTML][HTML] Role of vitamin D in osteoarthritis: molecular, cellular, and clinical perspectives
T Mabey, S Honsawek - International journal of endocrinology, 2015 - hindawi.com
Osteoarthritis is a debilitating and degenerative disease which affects millions of people
worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood …
worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood …
Synovial fluid biomarkers in knee osteoarthritis: a systematic review and quantitative evaluation using BIPEDs criteria
A Boffa, G Merli, L Andriolo, C Lattermann… - Cartilage, 2021 - journals.sagepub.com
Objective The aim of this systematic review was to analyze the evidence about the efficacy of
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …