Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Differentiation of insulin-producing pancreatic β cells from induced pluripotent stem cells
(iPSCs) derived from patients with diabetes promises to provide autologous cells for …

Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or
adult stem cells cultured under laboratory conditions, emerge as a captivating model and …

Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Recapitulation of embryonic pancreatic development has enabled development of methods
for in vitro islet cell differentiation using human pluripotent stem cells (hPSCs), which have …

Extracellular matrix (ECM) plays a multitude of roles, including supporting cells through
structural and biochemical interactions. ECM is damaged in the process of isolating human …

Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …